Isopropanol → Isopropyl 2-[2-phenyl-5-(3-thienyl)-4-oxazolyl]acetate

HRID 1462407Notes

Reaction equation

[C:1]1([C:7]2[O:8][C:9]([C:16]3[CH:20]=[CH:19][S:18][CH:17]=3)=[C:10]([CH2:12][C:13]([OH:15])=[O:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)(Cl)=O.[CH:25](O)([CH3:27])[CH3:26]>>[C:1]1([C:7]2[O:8][C:9]([C:16]3[CH:20]=[CH:19][S:18][CH:17]=3)=[C:10]([CH2:12][C:13]([O:15][CH:25]([CH3:27])[CH3:26])=[O:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 3

HCID 3776Isopropanol

HCID 24386Thionyl Chloride

HCID 131054392-[2-Phenyl-5-(3-thienyl)-4-oxazolyl]acetic acid

Product 1

HCID 13105444Isopropyl 2-[2-phenyl-5-(3-thienyl)-4-oxazolyl]acetateYield 43%

Procedure

2 g of 2-[2-phenyl-5-(3-thienyl)-4-oxazolyl]acetic acid, 3 g of thionyl chloride and 30 ml of isopropanol are treated in the same manner as described in Example 13. One g of isopropyl 2-[2-phenyl-5-(3-thienyl)-4-oxazolyl]acetate is obtained. Yield: 43%

Sources & evidence

ORD record: ord-49243c4e141c4cddb9903f36fb1294a8
Source dataset: uspto-grants-1984_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04460596

Reaction notes

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