1-Butanol → HCID 13105448, compound

HRID 1462410Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:17]3[CH:21]=[CH:20][S:19][CH:18]=3)=[C:11]([CH2:13][C:14]([OH:16])=[O:15])[N:12]=2)=[CH:4][CH:3]=1.[OH-].[K+].C(Cl)(=O)C(Cl)=O.[CH2:30](O)[CH2:31][CH2:32][CH3:33]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:17]3[CH:21]=[CH:20][S:19][CH:18]=3)=[C:11]([CH2:13][C:14]([O:16][CH2:30][CH2:31][CH2:32][CH3:33])=[O:15])[N:12]=2)=[CH:4][CH:3]=1

Participants

Reactant 4

HCID 2631-Butanol

HCID 14797Potassium Hydroxide

HCID 65578Oxalyl chloride

HCID 30697874-Oxazoleacetic acid, 2-(p-fluorophenyl)-5-(3-thienyl)-

Product 1

HCID 13105448HCID 13105448, compoundYield 42.2%

Procedure

2 g of 2-[2-(4-fluorophenyl)-5-(3-thienyl)-4-oxazolyl]acetic acid, 0.5 g of potassium hydroxide, 4.2 g of oxalyl chloride and 20 ml of n-butanol are treated in the same manner as described in Example 17. One g of n-butyl 2-[2-(4-fluorophenyl)-5-(3-thienyl)-4-oxazolyl]acetate is thereby obtained. Yield: 42.2%

Sources & evidence

ORD record: ord-f51f1ce18588414bbab4aacce861f7db
Source dataset: uspto-grants-1984_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04460596

Reaction notes

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