1-Butanol → n-Butyl 2-[2-(4-chlorophenyl)-5-(3-thienyl)-4-oxazolyl]acetate

HRID 1462413Notes

Reaction equation

HRID 1462413 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:17]3[CH:21]=[CH:20][S:19][CH:18]=3)=[C:11]([CH2:13][C:14]([OH:16])=[O:15])[N:12]=2)=[CH:4][CH:3]=1.[I-].ClC1[CH:29]=[CH:28][CH:27]=[CH:26][N+]=1C.C(O)CCC>C(N(CC)CC)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:17]3[CH:21]=[CH:20][S:19][CH:18]=3)=[C:11]([CH2:13][C:14]([O:16][CH2:26][CH2:27][CH2:28][CH3:29])=[O:15])[N:12]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 2631-ButanolHCID 1670692-Chloro-1-methylpyridinium iodideHCID 131054402-[2-(4-Chlorophenyl)-5-(3-thienyl)-4-oxazolyl]acetic acid

Product 1

HCID 13105451n-Butyl 2-[2-(4-chlorophenyl)-5-(3-thienyl)-4-oxazolyl]acetateYield 69.6%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

0.55 g of 2-[2-(4-chlorophenyl)-5-(3-thienyl)-4-oxazolyl]acetic acid, 0.44 g of 2-chloro-1-methyl-pyridinium iodide, 0.13 ml of n-butanol and 0.2 g of triethylamine are treated in the same manner as described in Example 20. 0.45 g of n-butyl 2-[2-(4-chlorophenyl)-5-(3-thienyl)-4-oxazolyl]acetate is thereby obtained.

Sources & evidence

ORD record
ord-e422d2ca544449b2b27b9a268a90f865
Source dataset
uspto-grants-1984_07
Patent number
US04460596

Reaction notes

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