Benzoyl chloride → N-benzoyl-N-[(3-thienylcarbonyl)methyl]amine

HRID 1462421Notes

Reaction equation

Cl.[S:2]1[CH:6]=[CH:5][C:4]([C:7]([CH2:9][NH2:10])=[O:8])=[CH:3]1.C(=O)(O)[O-].[Na+].[C:16](Cl)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:16]([NH:10][CH2:9][C:7]([C:4]1[CH:5]=[CH:6][S:2][CH:3]=1)=[O:8])(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

Reactant 3

HCID 7412Benzoyl chloride

HCID 516892Sodium Bicarbonate

HCID 131054172-Amino-1-(3-thienyl)ethanone hydrochloride

Product 1

HCID 13105427N-benzoyl-N-[(3-thienylcarbonyl)methyl]amineYield 95.1%

Procedure

4 g of N-[(3-thienylcarbonyl)methyl]amine hydrochloride, 8 g of sodium bicarbonate and 3.6 g of benzoyl chloride are treated in the same manner as described in Preparation 1-(3). 5.25 g of N-benzoyl-N-[(3-thienylcarbonyl)methyl]amine are thereby obtained.

Workup

customas described in Preparation 1-(3)

Sources & evidence

ORD record: ord-a84de10dd2d546fe8d3fcde273ed33d6
Source dataset: uspto-grants-1984_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04460596

Reaction notes

Loading…