4-Chlorobenzoyl chloride → N-(4-chlorobenzoyl)-N-[(2-thienylcarbonyl)methyl]amine

HRID 1462426Notes

Reaction equation

Cl.[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([CH2:9][NH2:10])=[O:8].C(=O)(O)[O-].[Na+].[Cl:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([NH:10][CH2:9][C:7]([C:3]2[S:2][CH:6]=[CH:5][CH:4]=2)=[O:8])=[O:22])=[CH:19][CH:18]=1

Participants

Reactant 3

HCID 85014-Chlorobenzoyl chloride

HCID 516892Sodium Bicarbonate

HCID 126098332-Amino-1-(thiophen-2-yl)ethan-1-one hydrochloride

Product 1

HCID 13105423N-(4-chlorobenzoyl)-N-[(2-thienylcarbonyl)methyl]amineYield 99.5%

Procedure

5.0 g of N-[(2-thienylcarbonyl)methyl]amine hydrochloride, 10.0 g of sodium bicarbonate and 4.78 g of 4-chlorobenzoyl chloride are treated in the same manner as described in Preparation 1-(3). 7.6 g of N-(4-chlorobenzoyl)-N-[(2-thienylcarbonyl)methyl]amine are thereby obtained.

Workup

customas described in Preparation 1-(3)

Sources & evidence

ORD record: ord-a2eb3f821adf42b497db155ae0a20373
Source dataset: uspto-grants-1984_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04460596

Reaction notes

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