Benzoyl chloride, 3-chloro- → N-(3-chlorobenzoyl)-N-[(3-thienylcarbonyl)methyl]amine

HRID 1462431Notes

Reaction equation

HRID 1462431 reaction equation
Cl.[S:2]1[CH:6]=[CH:5][C:4]([C:7]([CH2:9][NH2:10])=[O:8])=[CH:3]1.C(=O)(O)[O-].[Na+].[Cl:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=1)[C:20](Cl)=[O:21]>>[Cl:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=1)[C:20]([NH:10][CH2:9][C:7]([C:4]1[CH:5]=[CH:6][S:2][CH:3]=1)=[O:8])=[O:21]

Participants

4

Reactant 3

HCID 69252Benzoyl chloride, 3-chloro-HCID 516892Sodium BicarbonateHCID 131054172-Amino-1-(3-thienyl)ethanone hydrochloride

Product 1

HCID 13105430N-(3-chlorobenzoyl)-N-[(3-thienylcarbonyl)methyl]amineYield 93.1%

Procedure

7.5 g of N-[(3-thienylcarbonyl)methyl]amine hydrochloride, 10.0 g of sodium bicarbonate and 8.86 g of 3-chlorobenzoyl chloride are treated in the same manner as described in Preparation 1-(3). 11.0 g of N-(3-chlorobenzoyl)-N-[(3-thienylcarbonyl)methyl]amine are thereby obtained.

Workup

  1. customas described in Preparation 1-(3)

Sources & evidence

ORD record
ord-38156cc5e28e49adb731aec2d3476634
Source dataset
uspto-grants-1984_07
Patent number
US04460596

Reaction notes

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