1-Phenylpiperazine → HCID 13806187, compound

HRID 1462893Notes

Reaction equation

HRID 1462893 reaction equation
Cl.[Br:2][C:3]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:6]2[N:7]([CH:13]([CH3:15])[CH3:14])[C:8]([CH2:10][CH2:11]Cl)=[N:9][C:5]=2[CH:4]=1.[C:22]1([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C([O-])(=O)CC(CC([O-])=O)(C([O-])=O)O>C(OCC)(=O)C>[Br:2][C:3]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:6]2[N:7]([CH:13]([CH3:15])[CH3:14])[C:8]([CH2:10][CH2:11][N:31]3[CH2:32][CH2:33][N:28]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:29][CH2:30]3)=[N:9][C:5]=2[CH:4]=1

Participants

5

Reactant 3

HCID 70961-PhenylpiperazineHCID 31348CitrateHCID 20452290HCID 20452290, compound

Product 1

HCID 13806187HCID 13806187, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

By following the procedure described in Example 16 but condensing 5-bromo-2-(2-chloroethyl)-1-(1-methylethyl)-1H-naphth[1,2-d]imidazole hydrochloride with 1-phenylpiperazine, the compound of the title is obtained. M.p. 211°-213° C. (from ethyl acetate). The corresponding citrate melts at 169°-171° C. with decomposition.

Workup

  1. customthe compound of the title is obtained

Sources & evidence

ORD record
ord-af6054ef789843f783a8f716ddc2b8bc
Source dataset
uspto-grants-1984_07
Patent number
US04461894

Reaction notes

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