反应详情

To a solution of 16 g of AlCl3 dissolved in 21.6 g of anisol was added dropwise 17.6 g of benzenesulfonyl chloride. The reaction mixture was heated to reflux for 8 hours and poured into 1N HCl solution containing ice. The resultant solution was extracted with ethyl acetate (100 ml×3), washed with 100 ml of saturated NaHCO3 aqueous solution, dried over Na2SO4 and concentrated to obtain residue, which was recrystallized from hexane-ethyl acetate to obtain 25 g of the title compound.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 8 hours
3. additioncontaining ice
4. extractionThe resultant solution was extracted with ethyl acetate (100 ml×3)
5. washwashed with 100 ml of saturated NaHCO3 aqueous solution
6. dry with materialdried over Na2SO4
7. concentrationconcentrated
8. customto obtain residue, which
9. customwas recrystallized from hexane-ethyl acetate