HCID 19090869, compound → HCID 19090866, compound

HRID 1463639Notes

Reaction equation

HRID 1463639 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)[CH:11]=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:20][PH:21](=[O:25])[O:22][CH2:23][CH3:24]>C(N(CC)CC)C>[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)[CH:11]([P:21]([CH3:20])(=[O:25])[O:22][CH2:23][CH3:24])[OH:12])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 19090869HCID 19090869, compoundHCID 178476777HCID 178476777, compound

Product 1

HCID 19090866HCID 19090866, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A solution of 1.46 g of 3-(N-tert.-butyloxycarbonylamino)-2-(4-chlorophenyl)-propionaldehyde, 0.54 g of ethyl methylphosphinate and 0.695 ml of triethylamine is heated to 100° for 2 hours. The reaction mixture is cooled to room temperature and chromatographed on silica gel to give ethyl 3-(N-tert.-butyloxycarbonylamino)-2-(4-chlorophenyl)-1-hydroxypropyl(methyl)phosphinate.

Workup

  1. customchromatographed on silica gel

Sources & evidence

ORD record
ord-32aaa26307d84181bf35ccec89c9feba
Source dataset
uspto-grants-1994_04
Patent number
US05300679

Reaction notes

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