Triethylamine → HCID 131718378, compound

HRID 1463765Notes

Reaction equation

HRID 1463765 reaction equation
C[C:2]([CH2:9][C:10]#[CH:11])([C:6](Cl)=[O:7])[C:3](Cl)=[O:4].[CH3:12][O:13][C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[CH2:16][NH2:17].C([N:24]([CH2:27][CH3:28])CC)C>ClCCl>[CH3:12][O:13][C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[CH2:16][NH:17][C:6](=[O:7])[CH:2]([C:9]#[C:10][CH3:11])[C:3]([NH:24][CH2:27][C:28]1[CH:20]=[CH:19][CH:18]=[CH:15][C:14]=1[O:13][CH3:12])=[O:4]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 812922-MethoxybenzylamineHCID 102307424HCID 102307424, compound

Product 1

HCID 131718378HCID 131718378, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4.69 g [59] (24.3 mmol) in 100 ml dichloromethane was carefully added dropwise to a mixture of 6.67 g of 2-methoxybenzyl amine (48.6 mmol) and 5.06 g of triethylamine (50 mmol) in 100 ml diochloromethane, with exclusion of moisture. The mixture was agitated at room temperature for a further three hours, then repeatedly extracted with chloroform after adding water. The organic phase was successively washed with 1N HCl, saturated potassium carbonate solution and water and dried over sodium sulphate.

Workup

  1. extractionrepeatedly extracted with chloroform
  2. additionafter adding water
  3. washThe organic phase was successively washed with 1N HCl, saturated potassium carbonate solution and water
  4. dry with materialdried over sodium sulphate

Sources & evidence

ORD record
ord-ec94b60954964364b5e09ac3cee3a3ef
Source dataset
uspto-grants-1994_04
Patent number
US05302370

Reaction notes

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