HRID14639

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：COc1cc(OC)c2c(CNC(=O)OC(C)(C)C)ncc(C(=O)N(C)CCc3ccccn3)c2c1

HCID68613832

未命名化合物

PRODUCTS

生成物

结构：COc1cc(OC)c2c(CN)ncc(C(=O)N(C)CCc3ccccn3)c2c1.Cl

HCID68614421

未命名化合物

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

As described in example 1, 57 mg of {6,8-dimethoxy-4-[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester was treated with HCl in EtOAc to give 74 mg (>100%) of 1-aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid methyl-(2-pyridin-2-yl-ethyl)-amide hydrochloride. MS: APCI (M+H) calc'd for C21H24N4O3+H 381.4; found 381.2.