Benzoyl isothiocyanate → N-benzoyl-N'-(4'-fluoro-2-biphenylyl)thiourea

HRID 1464099Notes

Reaction equation

HRID 1464099 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1.[C:15]([N:23]=[C:24]=[S:25])(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>ClCCl>[C:15]([NH:23][C:24]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1)=[S:25])(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 68284Benzoyl isothiocyanateHCID 27589754'-Fluoro(1,1'-biphenyl)-2-amine

Product 1

HCID 15175510N-benzoyl-N'-(4'-fluoro-2-biphenylyl)thiourea

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 2-amino-4'-fluorobiphenyl (1.5 g) and benzoylisothiocyanate (1.3 g) in dichloromethane (20 ml) was heated under reflux for 6 hours to yield N-benzoyl-N'-(4'-fluoro-2-biphenylyl)thiourea as a colourless solid (m.p. 123°-124° C.).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 6 hours

Sources & evidence

ORD record
ord-895e4a33b77141418daa291b1570a39e
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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