Piperidin-4-ol → HCID 178511981, compound

HRID 1464102Notes

Reaction equation

HRID 1464102 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH:14][C:15]#[N:16])=[CH:4][CH:3]=1.[OH:17][CH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH:14][C:15]([N:21]2[CH2:22][CH2:23][CH:18]([OH:17])[CH2:19][CH2:20]2)=[NH:16])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 79341Piperidin-4-olHCID 19089180HCID 19089180, compound

Product 1

HCID 178511981HCID 178511981, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4'-fluoro-2-biphenylylcyanamide (1 g) and 4-hydroxypiperidine (0.6 g) in ethanol (10 ml) was heated at 90°-95° C. for 3 hours to give N-(4'-fluoro-2-biphenylyl)-4-hydroxypiperidine-1-carboxamidine as a colourless solid (m.p. 132°-133° C.) which was recrystallised from ethylacetate.

Workup

  1. temperaturewas heated at 90°-95° C. for 3 hours

Sources & evidence

ORD record
ord-260915f8077b4aa793087977ec1a65eb
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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