1-Methylpiperazine → HCID 178481027, compound

HRID 1464111Notes

Reaction equation

HRID 1464111 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH:14][C:15]#[N:16])[CH:5]=[CH:6][CH:7]=1.[CH3:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>COCCOC>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH:14][C:15]([N:21]2[CH2:22][CH2:23][N:18]([CH3:17])[CH2:19][CH2:20]2)=[NH:16])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 19089315HCID 19089315, compound

Product 1

HCID 178481027HCID 178481027, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

A mixture of 3'-fluoro-2-biphenylylcyanamide (4.1 g) and N-methylpiperazine (1.9 g) in 1,2-dimethoxyethane (30 ml) was heated at 90°-95° C. for 4 hours to yield N-(3'-fluoro-2-biphenylyl)-4-methylpiperazine-1-carboxamidine (m.p. 117°-118° C.) which was recrystallised from hexane.

Workup

  1. temperaturewas heated at 90°-95° C. for 4 hours

Sources & evidence

ORD record
ord-cd6f64d33bc84969a71921babcb6c919
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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