p-Toluenesulfonic acid → HCID 86747771, compound

HRID 1464311Notes

Reaction equation

HRID 1464311 reaction equation
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:3][CH:2]=1.[N:12]1[CH:17]=[CH:16][C:15]([CH:18]2[CH2:23][NH:22][CH2:21][CH2:20][N:19]2[C:24]2[N:25]=[CH:26][C:27]3[CH2:32][C:31](=[O:33])[N:30]([CH3:34])[C:28]=3[N:29]=2)=[CH:14][CH:13]=1>C(Cl)(Cl)Cl.CO>[C:1]1([CH3:11])[CH:2]=[CH:3][C:4]([S:7]([OH:10])(=[O:8])=[O:9])=[CH:5][CH:6]=1.[N:12]1[CH:13]=[CH:14][C:15]([CH:18]2[CH2:23][NH:22][CH2:21][CH2:20][N:19]2[C:24]2[N:25]=[CH:26][C:27]3[CH2:32][C:31](=[O:33])[N:30]([CH3:34])[C:28]=3[N:29]=2)=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 53656189HCID 53656189, compound

Product 1

HCID 86747771HCID 86747771, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent2×

Procedure

A solution of p-toluenesulfonic acid (0.1 g; 0.6 mmole) in 5 ml of chloroform-methanol was dissolved in a solution of 0.18 g (0.6 mmole) of 2-(4-pyridyl-piperazino)-5,6-dihydro-7-methyl-6-oxo(7H) pyrrolo[2,3-d]-pyrimidine in 30 ml of chloroform-methanol, and the mixed solution was stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure. The precipitated crystals were washed with hexane to give 0.25 g (yield 90%) of the desired compound.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. washThe precipitated crystals were washed with hexane

Sources & evidence

ORD record
ord-d76d10e29fa74e84a22684e6ceec0982
Source dataset
uspto-grants-1994_04
Patent number
US05304555

Reaction notes

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