Hydrochloric Acid → HCID 19087827, compound

HRID 1464341Notes

Reaction equation

HRID 1464341 reaction equation
C([O:4][CH2:5][CH2:6][O:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[N:14]=[C:13]([CH2:18][CH2:19][CH3:20])[N:12]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[N:38]([CH2:39][O:40][CH3:41])[N:37]=[N:36][N:35]=3)=[CH:24][CH:23]=1)[C:11]2=[O:42])(=O)C.C1COCC1.[OH-].[Na+].Cl>CO>[OH:4][CH2:5][CH2:6][O:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[N:14]=[C:13]([CH2:18][CH2:19][CH3:20])[N:12]([CH2:21][C:22]1[CH:23]=[CH:24][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[N:38]([CH2:39][O:40][CH3:41])[N:37]=[N:36][N:35]=3)=[CH:26][CH:27]=1)[C:11]2=[O:42]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 19087821HCID 19087821, compound

Product 1

HCID 19087827HCID 19087827, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 6-(2-acetoxyethyloxy)-3-[[2'-(N-methoxymethyltetrazol-5-yl)biphenyl-4-yl]methyl]-2-propyl-4(3H)-quinazolinone (0.42 g) in a mixture of methanol (3 ml), THF (2 ml) and 1N aqueous sodium hydroxide (1.5 ml) was stirred at room temperature for 1 hour. After addition of 1N hydrochloric acid (1.5 ml), the reaction mixture was extracted with ethyl acetate and the extract was washed with water, dried and evaporated to dryness. The residue was purified by column chromatography on silica gel to give a white powder.

Workup

  1. extractionthe reaction mixture was extracted with ethyl acetate
  2. washthe extract was washed with water
  3. customdried
  4. customevaporated to dryness
  5. customThe residue was purified by column chromatography on silica gel
  6. customto give a white powder

Sources & evidence

ORD record
ord-c8c2159efdc641289614d15d6d0be195
Source dataset
uspto-grants-1994_04
Patent number
US05304565

Reaction notes

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