Hydrochloric Acid → HCID 19025745, compound

HRID 1464401Notes

Reaction equation

HRID 1464401 reaction equation
[CH2:1]([C:5]1[CH:6]=[C:7]([CH:23]([CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[C:24]([O:26]C)=[O:25])[CH:8]=[CH:9][C:10]=1[O:11][CH2:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]=1)[CH:2]([CH3:4])[CH3:3].[OH-].[Na+].Cl>CC(O)C>[CH2:1]([C:5]1[CH:6]=[C:7]([CH:23]([CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[C:24]([OH:26])=[O:25])[CH:8]=[CH:9][C:10]=1[O:11][CH2:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]=1)[CH:2]([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19025748HCID 19025748, compound

Product 1

HCID 19025745HCID 19025745, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

10.2 g (0.0236 mol) of the compound of Example 80 are taken up in 70 ml of 2-propanol and the solution is heated to boiling point overnight with 50 ml of 1N sodium hydroxide solution. After the mixture has become cold it is neutralised with 50 ml of 1N hydrochloric acid. The precipitate obtained is filtered off with suction, washed and dried and then recrystallised from diisopropyl ether.

Workup

  1. customThe precipitate obtained
  2. filtrationis filtered off with suction
  3. washwashed
  4. customdried
  5. customrecrystallised from diisopropyl ether

Sources & evidence

ORD record
ord-7613925b208d40878f82467d1487ee45
Source dataset
uspto-grants-1994_04
Patent number
US05304563

Reaction notes

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