Hydrochloric Acid → 1-(3-Hydroxy-2-fluoro)propylimidazole

HRID 1464424Notes

Reaction equation

HRID 1464424 reaction equation
[F:1][CH:2]([CH2:12][O:13]C(=O)C)[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[N+:9]([O-:11])=[O:10].Cl>>[F:1][CH:2]([CH2:12][OH:13])[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[N+:9]([O-:11])=[O:10]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 15077085HCID 15077085, compound

Product 1

HCID 134352651-(3-Hydroxy-2-fluoro)propylimidazoleYield 37.6%

Procedure

To 910 mg (3.94 mmol) of 1-(2'-fluoro-3'-acetoxypropyl)-2-nitroimidazole, 6N-HCl was added and stirred overnight at room temperature. The reaction mixture was concentrate and subjected to isolation and purification by silica gel column chromatography to give 280 mg of 1-(2'-fluoro-3'-hydroxypropyl)-2-nitroimidazole.

Workup

  1. concentrationThe reaction mixture was concentrate
  2. customsubjected to isolation and purification by silica gel column chromatography

Sources & evidence

ORD record
ord-6f467fb9eb57416cb9b494e67e25c81c
Source dataset
uspto-grants-1994_04
Patent number
US05304654

Reaction notes

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