反应详情

温度

120 °C

12 Grams of 2-nitro-5-chlorobenzaldehyde dimethyl acetal, 16.3 g of 4-acetylaminopiperidine hydrochloride, 13.7 g of sodium carbonate and 13 ml of triethylamine in 150 ml of N-methylpyrrolidone solution were mixed together and reacted by heating at 120° C for 12 hours with stirring under nitrogen gas stream. After the reaction was completed, the solvent was removed by evaporation and thus obtained residue was added with water and extracted with dichloromethane, then the extract was washed with water and with an aqueous solution saturated with sodium chlor:de, then dried with anhydrous sodium sulfate. The solvent was removed by evaporation and the residue thus obtained was added with diethyl ether, then the crystals formed were collected by filtration to yield 11.2 g of 2-nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde dimethylacetal.

1. customreacted
2. customthe solvent was removed by evaporation and thus obtained residue
3. additionwas added with water
4. extractionextracted with dichloromethane
5. washthe extract was washed with water and with an aqueous solution saturated with sodium chlor
6. dry with materialde, then dried with anhydrous sodium sulfate
7. customThe solvent was removed by evaporation
8. customthe residue thus obtained
9. customthe crystals formed
10. filtrationwere collected by filtration