2-Oxobutanoic Acid → L-Aspartic Acid

HRID 1464623Notes

Reaction equation

HRID 1464623 reaction equation
O=C(CC)C(O)=O.O=C(CCC)C(O)=O.CC(C)CC(=O)C(O)=O.O[CH:26]([C:32]([OH:34])=[O:33])[C@@H:27]([C:29]([OH:31])=[O:30])[NH2:28]>>[NH2:28][C@H:27]([C:29]([OH:31])=[O:30])[CH2:26][C:32]([OH:34])=[O:33]

Participants

5

Reactant 4

HCID 582-Oxobutanoic AcidHCID 704-Methyl-2-oxovaleric acidHCID 745632-Oxovaleric acidHCID 44017581601-40-3

Product 1

HCID 5960L-Aspartic Acid

Procedure

β-hydroxy, aspartic acid derviatives 12b-d were prepared from copperglycinate and 2-oxobutanoic acid, 2-oxopentanoic acid and 4-methyl,2-oxopentanoic acid, respectively, according to the procedure described by L. Benoiton et al. (J. Am. Chem. Soc, 81, 1726-1729, 1959). β-Hydroxyaspartic acid was obtained from Sigma Chem. Comp.

Sources & evidence

ORD record
ord-decc8a782cdc4395a9b7b6cc2b008839
Source dataset
uspto-grants-1994_04
Patent number
US05306809

Reaction notes

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