反应详情

温度

150 °C

A mixture of (5-iodo-1-methyl-1H-pyrazol-3-yl) (4-(6-isobutoxypyrimidin-4-yl)piperazin-1-yl)methanone (20 mg, 0.043 mmol), (6-methoxypyridin-3-yl)boronic acid (8.5 mg, 0.055 mmol), palladium acetate (1.9 mg), triphenylphosphine (4.5 mg), and sodium carbonate (18 mg, 0.17 mmol) in dioxane-THF-water (1.6 mL, 1:0.3:0.3) was stirred at 150° C. for 10 min under microwave irradiation. After cooling to rt, the mixture was poured onto water, and the aqueous layer was extracted with EtOAc (three times). The combined organic layer was concentrated in vacuo. The residue was purified by preparative LC-MS to give 6.5 mg (34% yields) of the title compound.

1. temperatureAfter cooling to rt
2. additionthe mixture was poured onto water
3. extractionthe aqueous layer was extracted with EtOAc (three times)
4. concentrationThe combined organic layer was concentrated in vacuo
5. customThe residue was purified by preparative LC-MS
6. customto give