反应详情

温度

35 °C

7-(Bromomethyl)-4-chlorothieno[3,2-d]pyrimidine (9.17 g, 33.0 mmol) was dissolved in DMF (54 mL) and then sodium acetate (27 g, 330 mmol) and potassium iodide (10.96 g, 66.0 mmol) were added thereto. The reaction mixture was stirred at 35° C. for 4 hours, diluted with ethyl acetate and washed with sat. sodium thiosulfate solution 5 times. The reaction mixture was dried with MgSO4, filtered, concentrated and purified by silica gel chromatography to obtain to obtain the title compound as a white solid.

1. washwashed with sat. sodium thiosulfate solution 5 times
2. dry with materialThe reaction mixture was dried with MgSO4
3. filtrationfiltered
4. concentrationconcentrated
5. custompurified by silica gel chromatography
6. customto obtain