Potassium Iodide → HCID 86674137, compound

HRID 1465003Notes

Reaction equation

HRID 1465003 reaction equation
Br[CH2:2][C:3]1[C:7]2[N:8]=[CH:9][N:10]=[C:11]([Cl:12])[C:6]=2[S:5][CH:4]=1.[C:13]([O-:16])(=[O:15])[CH3:14].[Na+].[I-].[K+]>CN(C=O)C.C(OCC)(=O)C>[C:13]([O:16][CH2:2][C:3]1[C:7]2[N:8]=[CH:9][N:10]=[C:11]([Cl:12])[C:6]=2[S:5][CH:4]=1)(=[O:15])[CH3:14]

Participants

6

Reactant 3

HCID 4875Potassium IodideHCID 517045Sodium AcetateHCID 18176289HCID 18176289, compound

Product 1

HCID 86674137HCID 86674137, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
35 °C

Procedure

7-(Bromomethyl)-4-chlorothieno[3,2-d]pyrimidine (9.17 g, 33.0 mmol) was dissolved in DMF (54 mL) and then sodium acetate (27 g, 330 mmol) and potassium iodide (10.96 g, 66.0 mmol) were added thereto. The reaction mixture was stirred at 35° C. for 4 hours, diluted with ethyl acetate and washed with sat. sodium thiosulfate solution 5 times. The reaction mixture was dried with MgSO4, filtered, concentrated and purified by silica gel chromatography to obtain to obtain the title compound as a white solid.

Workup

  1. washwashed with sat. sodium thiosulfate solution 5 times
  2. dry with materialThe reaction mixture was dried with MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. custompurified by silica gel chromatography
  6. customto obtain

Sources & evidence

ORD record
ord-e0a864a7a29d4d9e92eae39da15b3b7c
Source dataset
uspto-grants-2015_04
Patent number
US08999973B2

Reaction notes

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