Sodium Hydroxide → HCID 86674138, compound

HRID 1465004Notes

Reaction equation

HRID 1465004 reaction equation
C([O:4][CH2:5][C:6]1[C:10]2[N:11]=[CH:12][N:13]=[C:14]([Cl:15])[C:9]=2[S:8][CH:7]=1)(=O)C.[OH-].[Na+]>C1COCC1.C(OCC)(=O)C>[Cl:15][C:14]1[C:9]2[S:8][CH:7]=[C:6]([CH2:5][OH:4])[C:10]=2[N:11]=[CH:12][N:13]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 86674137HCID 86674137, compound

Product 1

HCID 86674138HCID 86674138, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

(4-Chlorothieno[3,2-d]pyrimidine-7-yl)methyl acetate (3.12 g, 12.06 mmol) was dissolved in THF (240 mL) and then 1N NaOH solution (100 mL) was added thereto at room temperature. The reaction mixture was stirred for 30 minutes, diluted with ethyl acetate, and the aqueous layer was extracted with ethyl acetate. The organic layer was dried with MgSO4, filtered and concentrated to obtain the title compound as a white solid without further purification.

Workup

  1. customat room temperature
  2. extractionthe aqueous layer was extracted with ethyl acetate
  3. dry with materialThe organic layer was dried with MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-5ed3caf074494f74bc7c975aa20da27b
Source dataset
uspto-grants-2015_04
Patent number
US08999973B2

Reaction notes

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