反应详情

温度

80 °C

The compound (27 g, 72.1 mmol) obtained in Step 2 of Preparation Example 6 was dissolved in ethanol (300 mL), SnCl2.2H2O (81 g, 360 mmol) was added thereto and stirred at 80° C. for 3 hours. The reaction mixture was cooled to room temperature and diluted with ethyl acetate. The organic layer was washed with sat. NaHCO3 solution several times. The organic layer was dried with anhydrous MgSO4, filtered and concentrated to obtain the title compound without further purification.

1. temperatureThe reaction mixture was cooled to room temperature
2. washThe organic layer was washed with sat. NaHCO3 solution several times
3. dry with materialThe organic layer was dried with anhydrous MgSO4
4. filtrationfiltered
5. concentrationconcentrated