反应详情

A solution of [4-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-6,7-dimethoxy-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester (81 mg, 0.17 mmol) in 2 mL EtOAc was treated with HCl (6N in dioxane) according to Example 1 to give (1-Aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-(3,4-dihydro-1H-isoquinolin-2-yl)-methanone as the hydrochloride salt (77 mg, 93%). MS: APCI (M+H) calc'd for C22H23N3O3+H 378.4; found 378.1.