Hydrochloric Acid → HCID 86695588, compound

HRID 1465722Notes

Reaction equation

HRID 1465722 reaction equation
[C@H:1]12[N:8](C(OC(C)(C)C)=O)[C@H:5]([CH2:6][CH2:7]1)[CH2:4][CH2:3][CH:2]2[C:16]([O:18][CH3:19])=[O:17].Cl>CCO.O1CCOCC1>[C@H:1]12[NH:8][C@H:5]([CH2:6][CH2:7]1)[CH2:4][CH2:3][CH:2]2[C:16]([O:18][CH3:19])=[O:17]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86695587HCID 86695587, compound

Product 1

HCID 86695588HCID 86695588, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To (1S,5S)-8-tert-butyl 2-methyl 8-azabicyclo[3.2.1]octane-2,8-dicarboxylate (5.49 g) in EtOH (1 mL) was added 4M HCl in dioxane (5 mL). The reaction mixture was stirred at room temperature for 2 hours. Concentrated to give crude product (3.45 g).

Workup

  1. concentrationConcentrated

Sources & evidence

ORD record
ord-9d914a03d06e488b878c7d4b215b9bd6
Source dataset
uspto-grants-2015_04
Patent number
US08999966B2

Reaction notes

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