Triethylsilane → HCID 56969446, compound

HRID 1465726Notes

Reaction equation

HRID 1465726 reaction equation
[F:1][C:2]1[CH:56]=[CH:55][CH:54]=[CH:53][C:3]=1[CH2:4][N:5]1[CH:10]2[CH2:11][CH2:12][CH:6]1[CH:7]([C:13]1[O:14][C:15]([C:18]3[CH:19]=[C:20]4[C:24](=[CH:25][CH:26]=3)[N:23](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[N:22]=[C:21]4[C:46]3[CH:51]=[CH:50][N:49]=[C:48]([CH3:52])[CH:47]=3)=[N:16][N:17]=1)[CH2:8][CH2:9]2.C([SiH](CC)CC)C>>[F:1][C:2]1[CH:56]=[CH:55][CH:54]=[CH:53][C:3]=1[CH2:4][N:5]1[CH:10]2[CH2:11][CH2:12][CH:6]1[CH:7]([C:13]1[O:14][C:15]([C:18]3[CH:19]=[C:20]4[C:24](=[CH:25][CH:26]=3)[NH:23][N:22]=[C:21]4[C:46]3[CH:51]=[CH:50][N:49]=[C:48]([CH3:52])[CH:47]=3)=[N:16][N:17]=1)[CH2:8][CH2:9]2

Participants

3

Reactant 2

HCID 12052TriethylsilaneHCID 67517760HCID 67517760, compound

Product 1

HCID 56969446HCID 56969446, compound

Procedure

To 2-(8-(2-Fluorobenzyl)-8-azabicyclo[3.2.1]octan-2-yl)-5-(3-(2-methylpyridin-4-yl)-1-trityl-1H-indazol-5-yl)-1,3,4-oxadiazole (40 mg, 0.054 mmol) 95% trifluoroacetic acid (3 mL) was added. The reaction was stirred at room temperature for 30 minutes. After reaction completion, triethylsilane (0.1 mL) was added. The reaction was concentrated and submitted for prep LC/MS. A total of 6 mg of purified compound was retrieved.

Workup

  1. additionwas added
  2. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-c798e4cbbf7c44fc8189388953f8e788
Source dataset
uspto-grants-2015_04
Patent number
US08999966B2

Reaction notes

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