反应详情

温度

110 °C

To a 250 mL flask charged with 5-Bromo-2,1,3-benzoxadiazole (5.0 g, 25 mmol), Palladium Tetrakis (0.87 g, 0.75 mmol), and lithium chloride (2.1 g, 50 mmol) was added Allyl Tri-n-butyltin (10 g, 30 mmol) and toluene (100 mL). The mixture was attached to a reflux condenser, sealed and purged with nitrogen. The reaction was heated to 110° C. for 2 hours. TLC showed good and complete reaction. The reaction was diluted with EtOAc, washed with brine, concentrated and purified by silica gel chromatography.

1. customThe mixture was attached to a reflux condenser
2. customsealed
3. custompurged with nitrogen
4. customcomplete reaction
5. washwashed with brine
6. concentrationconcentrated
7. custompurified by silica gel chromatography