Iodine → HCID 178526522, compound

HRID 1466483Notes

Reaction equation

HRID 1466483 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][N:10]=[CH:9]2)([O-:3])=[O:2].[OH-].[K+].[I:15]I>CN(C=O)C.S(=O)(O)[O-].[Na+]>[I:15][C:9]1[C:8]2[C:12](=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[CH:6][CH:7]=2)[NH:11][N:10]=1

Participants

6

Reactant 3

HCID 807IodineHCID 18937-NitroindazoleHCID 14797Potassium Hydroxide

Product 1

HCID 178526522HCID 178526522, compoundYield 88.3%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 23665763Sodium BisulfiteSolvent

Procedure

7-Nitroindazole (1.60 g, 9.80 mmol) was dissolved in DMF (100 mL), and potassium hydroxide (2.20 g, 39.20 mmol) and iodine (4.98 g, 19.61 mmol) were added in drops thereto. After stirring for 2 h, the reaction mixture was diluted with 10% aqueous sodium bisulfite solution. The resulting solid was collected and dried to give the title compound (2.50 g, Yield 88%).

Workup

  1. customThe resulting solid was collected
  2. customdried

Sources & evidence

ORD record
ord-f23e07fba7b6417d8854e8f439563abc
Source dataset
uspto-grants-2015_04
Patent number
US09000028B2

Reaction notes

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