HRID1466525
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 100 °C
PROCEDURE
实验过程
7-Amino-5-chloro-2-phenyl-1H-indole (200 mg, 0.82 mmol) prepared in Example 3 was dissolved in toluene (30 mL). 2-Bromopyridine (182 mg, 1.15 mmol), Pd2(dba)3, Xantphos (42 mg, 0.07 mmol) and Na2CO3 were added thereto. The mixture was degassed, and stirred for 12 h at 100° C. After completion of the reaction, the reaction mixture was filtered through a cellite. The solvent was removed under reduced pressure, and the residue was purified by column chromatography (eluent: EtOAc/n-Hex=1/3) to give the title compound (25 mg, Yield 13%).
WORKUP
后处理
- customThe mixture was degassed
- customAfter completion of the reaction
- filtrationthe reaction mixture was filtered through a cellite
- customThe solvent was removed under reduced pressure
- customthe residue was purified by column chromatography (eluent: EtOAc/n-Hex=1/3)