反应详情

Tritylchloride (2.05 g. 7.36 mmol) was added to a solution of di-tert-butyl L-glutamate hydrochloride (2.15 g, 7.27 mmol) and triethylamine (5 mL, 36 mmol) in dichloromethane (20 mL). The solution was stirred for overnight (16 h) at room temperature. The solution was washed with sodium bicarbonate solution (3×10 mL) and water (2×5 mL). After drying over sodium sulphate, the solvent was evaporated. The crude product was purified by flash chromatography (ethyl acetate/n-hexane: 2/98 to 3/97) to give di-tert-butyl N-trityl-L-glutamate (3.2 g, 88%) as a white foam.

1. washThe solution was washed with sodium bicarbonate solution (3×10 mL) and water (2×5 mL)
2. dry with materialAfter drying over sodium sulphate
3. customthe solvent was evaporated
4. customThe crude product was purified by flash chromatography (ethyl acetate/n-hexane: 2/98 to 3/97)