Trifluoroacetic acid → HCID 86693908, compound

HRID 1466743Notes

Reaction equation

HRID 1466743 reaction equation
[F:1][C:2]1[CH:23]=[CH:22][C:21]([CH2:24][C:25]2[C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:28](=[O:35])[NH:27][N:26]=2)=[CH:20][C:3]=1[C:4]([N:6]1[CH2:11][C@@H:10]2[CH2:12][C@H:7]1[CH2:8][N:9]2C(OC(C)(C)C)=O)=[O:5].[C:36]([OH:42])([C:38]([F:41])([F:40])[F:39])=[O:37]>C(Cl)Cl>[OH:42][C:36]([C:38]([F:41])([F:40])[F:39])=[O:37].[C@H:7]12[CH2:12][C@H:10]([NH:9][CH2:8]1)[CH2:11][N:6]2[C:4]([C:3]1[CH:20]=[C:21]([CH:22]=[CH:23][C:2]=1[F:1])[CH2:24][C:25]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:28](=[O:35])[NH:27][N:26]=1)=[O:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86693907HCID 86693907, compound

Product 1

HCID 86693908HCID 86693908, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the solution of (1S,4S)-tert-butyl 5-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)-2,5-diazabicyclo[2,2,1]heptane-2-carboxylate (1.23 g crude obtained from previous step) in DCM (50 ml) was added TFA (4 ml), and stirred for 16 h at room temperature. The reaction mixture was concentrated under vacuo to yield the crude product as yellow oil (2.64 g), used in next step without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated under vacuo

Sources & evidence

ORD record
ord-8a80eec360a1481eb163f652941e8e35
Source dataset
uspto-grants-2015_04
Patent number
US08999985B2

Reaction notes

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