Trifluoroacetic acid → HCID 86693909, compound

HRID 1466744Notes

Reaction equation

HRID 1466744 reaction equation
[F:1][C:2]1[CH:23]=[CH:22][C:21]([CH2:24][C:25]2[C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:28](=[O:35])[NH:27][N:26]=2)=[CH:20][C:3]=1[C:4]([N:6]1[CH2:12][CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]1)=[O:5].[C:36]([OH:42])([C:38]([F:41])([F:40])[F:39])=[O:37]>C(Cl)Cl>[OH:42][C:36]([C:38]([F:41])([F:40])[F:39])=[O:37].[N:6]1([C:4]([C:3]2[CH:20]=[C:21]([CH:22]=[CH:23][C:2]=2[F:1])[CH2:24][C:25]2[C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:28](=[O:35])[NH:27][N:26]=2)=[O:5])[CH2:12][CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 25131910HCID 25131910, compound

Product 1

HCID 86693909HCID 86693909, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the solution of the crude tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)-1,4-diazepane-1-carboxylate (370 mg crude obtained from previous step) in DCM (20 ml) was added TFA (1 ml) and stirred for 14 h at room temperature. The reaction mixture was concentrated under vacuo to yield the crude product as yellow oil (300 mg), used in next step without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated under vacuo

Sources & evidence

ORD record
ord-a77868e6c31946779a1b92f3ad065a6b
Source dataset
uspto-grants-2015_04
Patent number
US08999985B2

Reaction notes

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