Lithium Hydroxide → HCID 66765609, compound

HRID 1466914Notes

Reaction equation

HRID 1466914 reaction equation
C([O:3][C:4]([C:6]1[N:7]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:8]2[C:13]([C:14]=1[S:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([Br:22])[CH:17]=1)=[CH:12][CH:11]=[C:10]([Cl:23])[CH:9]=2)=[O:5])C.[Li+].[OH-]>CO>[CH2:24]([N:7]1[C:8]2[C:13](=[CH:12][CH:11]=[C:10]([Cl:23])[CH:9]=2)[C:14]([S:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([Br:22])[CH:17]=2)=[C:6]1[C:4]([OH:5])=[O:3])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 66765142HCID 66765142, compound

Product 1

HCID 66765609HCID 66765609, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

1-Benzyl-3-(3-bromo-phenylsulfanyl)-6-chloro-1H-indole-2-carboxylic acid ethyl ester (0.520 g, 1.04 mmol) was dissolved in MeOH:THE (1:1, 10 mL) and LiOH (5 mL, 1.0M aq., 5 mmol) was added. The reaction was heated to 50° C. for 1 hour then removed from heat and submitted to aqueous workup to give the title compound which was carried to the next step without further purification.

Workup

  1. customthen removed
  2. temperaturefrom heat

Sources & evidence

ORD record
ord-63fe7758218b4644adb035b9618aa07a
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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