3-{6-Chloro-7-fluoro-1-[1-(4-methoxy-benzyl)-1H-pyrazol-4-yl]-2-methyl-1H-indol-3-ylsulfanyl}-benzoic acid ethyl ester → 3-[6-Chloro-7-fluoro-2-methyl-1-(1H-pyrazol-4-yl)-1H-indol-3-ylsulfanyl]-benzoic acid ethyl ester

HRID 1466939Notes

Reaction equation

HRID 1466939 reaction equation
[CH2:1]([O:3][C:4](=[O:38])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[C:16]([F:22])[C:17]([Cl:21])=[CH:18][CH:19]=3)[N:14]([C:23]3[CH:24]=[N:25][N:26](CC4C=CC(OC)=CC=4)[CH:27]=3)[C:13]=2[CH3:37])[CH:6]=1)[CH3:2]>C(O)(C(F)(F)F)=O>[CH2:1]([O:3][C:4](=[O:38])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[C:16]([F:22])[C:17]([Cl:21])=[CH:18][CH:19]=3)[N:14]([C:23]3[CH:27]=[N:26][NH:25][CH:24]=3)[C:13]=2[CH3:37])[CH:6]=1)[CH3:2]

Participants

3

Reactant 1

HCID 667657853-{6-Chloro-7-fluoro-1-[1-(4-methoxy-benzyl)-1H-pyrazol-4-yl]-2-methyl-1H-indol-3-ylsulfanyl}-benzoic acid ethyl ester

Product 1

HCID 667648833-[6-Chloro-7-fluoro-2-methyl-1-(1H-pyrazol-4-yl)-1H-indol-3-ylsulfanyl]-benzoic acid ethyl ester

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

3-{6-Chloro-7-fluoro-1-[1-(4-methoxy-benzyl)-1H-pyrazol-4-yl]-2-methyl-1H-indol-3-ylsulfanyl}-benzoic acid ethyl ester (0.10 g, 0.18 mmol) was stirred in neat TFA (4 mL) for 18 hrs.

Sources & evidence

ORD record
ord-bbd4900e50fe43bcae03225c63550623
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Reaction notes

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