反应详情

3-(6-Chloro-1-cyano-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester (0.45 g, 1.15 mmol), hydroxylamine hydrochloride (0.40 g, 5.79 mmol), and potassium carbonate (0.80 g, 5.79 mmol) were combined in absolute EtOH (4 mL) and stirred at reflux for overnight. The heterogeneous mixture was then filtered, and the solids were washed with hot absolute EtOH (2×10 mL). The resulting filtrate was concentrated to dryness under reduced pressure to afford the title compound.

1. temperatureat reflux for overnight
2. filtrationThe heterogeneous mixture was then filtered
3. washthe solids were washed with hot absolute EtOH (2×10 mL)
4. concentrationThe resulting filtrate was concentrated to dryness under reduced pressure