Hydrochloric Acid → HCID 66746694, compound

HRID 1467028Notes

Reaction equation

HRID 1467028 reaction equation
[NH2:1][C:2]1[C:3]([C:23]#[N:24])=[C:4]([CH:20]=[CH:21][CH:22]=1)[O:5][CH2:6][CH:7]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]1.Cl>CCOC(C)=O>[NH2:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:4]([O:5][CH2:6][CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[C:3]=1[C:23]#[N:24]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66746807HCID 66746807, compound

Product 1

HCID 66746694HCID 66746694, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl 4-((3-amino-2-cyanophenoxy)methyl)piperidine-1-carboxylate (Example 34d, 1.33 g, 4.0 mmol) in EtOAc (20 mL) was added dropwise aqueous HCl solution (12 N, 6.6 mL) at 0° C. The reaction mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure to give the title compound (100%) as a brown solid, which is pure enough and used directly in the next step without further purification. MS 232 (MH+).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-659a7559fe4e4f6c8966b9b0118b824c
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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