Sodium ion → 1,1-Dimethylethyl (2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)[1-(2-hydroxy-1-{[(phenylmethyl)oxy]methyl}ethyl)-4-piperidinyl]carbamate

HRID 146707Notes

Reaction equation

HRID 146707 reaction equation
[Al+3:41].[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1.[H-:40].[H-:43].[H-:44].[H-:45].[Li+:42].[Na+:48].[O:1]1[CH2:2][CH2:3][O:4][c:5]2[cH:6][n:7][c:8]([CH2:11][N:12]([CH:13]3[CH2:14][CH2:15][N:16]([CH:19]([C:20](=[O:21])[O:22][CH3:23])[CH2:24][O:25][CH2:26][c:27]4[cH:28][cH:29][cH:30][cH:31][cH:32]4)[CH2:17][CH2:18]3)[C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[cH:9][c:10]21.[OH-:47].[OH2:46]>>[O:1]1[CH2:2][CH2:3][O:4][c:5]2[cH:6][n:7][c:8]([CH2:11][N:12]([CH:13]3[CH2:14][CH2:15][N:16]([CH:19]([CH2:20][OH:21])[CH2:24][O:25][CH2:26][c:27]4[cH:28][cH:29][cH:30][cH:31][cH:32]4)[CH2:17][CH2:18]3)[C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[cH:9][c:10]21

Participants

9

Reactant 8

HCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 68597436Methyl 2-[4-((2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl){[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]-3-[(phenylmethyl)oxy]propanoate

Product 1

HCID 686151121,1-Dimethylethyl (2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)[1-(2-hydroxy-1-{[(phenylmethyl)oxy]methyl}ethyl)-4-piperidinyl]carbamate

Sources & evidence

ORD record
ord-e0ba4b7766214dc386bb9400c836696c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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