Hydrochloric Acid → 3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxylic acid

HRID 1467313Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([O:19]CC)=[O:18])[CH:15]=3)[N:10]([C:22]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:9]=2)[CH:5]=[CH:4][N:3]=1.CO.[OH-].[Na+].Cl>C(O)(C)C.C(Cl)(Cl)Cl>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([OH:19])=[O:18])[CH:15]=3)[N:10]([C:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)([C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[N:9]=2)[CH:5]=[CH:4][N:3]=1

Participants

Conditions

Temperature: 80 °C

Procedure

In a sealed flask was added ethyl 3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxylate (420 mg, 0.802 mmol), MeOH (6 ml), and sodium hydroxide (1N in water, 4 ml, 4.00 mmol). The resulting mixture was then heated for 60 min at a temperature of 80° C. with stirring. The mixture was then neutralized with HCl (2N in water), diluted with 10% isopropanol in chloroform, washed with water, dried with sodium sulfate, filtered, and concentrated to afford 3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxylic acid (392 mg, 0.791 mmol) as a light yellow solid. The crude product was progressed to the next step without purification.

Workup

washwashed with water
dry with materialdried with sodium sulfate
filtrationfiltered
concentrationconcentrated

Sources & evidence

ORD record: ord-7fe3d1c8fcca471b8d6273e8759085f1
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08999957B2

Reaction notes

Loading…