Hydrochloric Acid → (S)-3-Amino-1-benzylpiperidine

HRID 1467330Notes

Reaction equation

HRID 1467330 reaction equation
Cl.[CH2:2]([N:9]1[CH2:14][CH2:13][CH2:12][C@H:11]([NH:15]C(=O)OC(C)(C)C)[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCOCC1>[CH2:2]([N:9]1[CH2:14][CH2:13][CH2:12][C@H:11]([NH2:15])[CH2:10]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10541535(S)-tert-Butyl (1-benzylpiperidin-3-yl)carbamate

Product 1

HCID 854131(S)-3-Amino-1-benzylpiperidine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4N HCl in dioxane (1 mL) was added to (S)-tert-butyl 1-benzylpiperidin-3-ylcarbamate (0.5 mmol). The reaction was stirred at room temperature for 30 minutes. The solvent was removed by vacuo. The crude product was progressed to the next step without purification.

Workup

  1. customThe solvent was removed by vacuo
  2. customThe crude product was progressed to the next step without purification

Sources & evidence

ORD record
ord-87ae1ec91eef4e5992f715c055b4aff8
Source dataset
uspto-grants-2015_04
Patent number
US08999957B2

Reaction notes

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