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HRID14677

反应详情

EQUATION

反应方程式

HRID 14677 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：COc1cc2c(CC(=O)N(C)Cc3ccccc3)cnc(CNC(=O)OC(C)(C)C)c2cc1OC
HCID68613397

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc2c(CC(=O)N(C)Cc3ccccc3)cnc(CN)c2cc1OC.Cl
HCID68613409

未命名化合物

收率 66%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

As described in Example 1, 60 mg of {4-[(benzyl-methyl-carbamoyl)-methyl]-6,7-dimethoxy-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester was treated with HCl in EtOAc to give 31 mg (66%) of 2-(1-aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-N-benzyl-N-methyl-acetamide hydrochloride. MS: APCI (M+H) calc'd for C22H25N3O3+H 380.5; found 380.1.