反应详情

温度

100 °C

Add molybedinum hexacarbonyl (0.07 g, 0.26 mmol) to 4-[5-(3-iodo-benzyl)-[1,3,4]oxadiazol-2-yl]-benzonitrile (0.10 g (0.26 mmol) in 2 mL of a 1:1 mixture of tetrahydrofuran MeOH in a microwave pressure tube. Add DBU (0.11 mL, 0.74 mmol) causing the solution to darken. Add palladium acetate (0.006 g, 0.030 mmol) to the mixture, seal the tube and heat at 100° C. in a microwave reactor for 10 minutes. Cool the mixture to room temperature and purify by flash silica gel chromatography to give 0.04 g 48% yield of 3-[5-(4-cyano-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-benzoic acid methyl ester a solid.

1. temperatureCool the mixture to room temperature
2. custompurify by flash silica gel chromatography