Sodium Carbonate → HCID 86710051, compound

HRID 1468273Notes

Reaction equation

HRID 1468273 reaction equation
[CH:1]([C:4]1[N:5]=[C:6]2[CH:11]=[C:10]([C:12]#[N:13])[C:9]([CH3:14])=[CH:8][N:7]2[CH:15]=1)([CH3:3])[CH3:2].[I:16]N1C(=O)CCC1=O.C(=O)([O-])[O-].[Na+].[Na+]>CN(C=O)C>[I:16][C:15]1[N:7]2[CH:8]=[C:9]([CH3:14])[C:10]([C:12]#[N:13])=[CH:11][C:6]2=[N:5][C:4]=1[CH:1]([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 120273N-IodosuccinimideHCID 86710049HCID 86710049, compound

Product 1

HCID 86710051HCID 86710051, compoundYield 92.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-Isopropyl-6-methylimidazo[1,2-a]pyridine-7-carbonitrile (500 mg, 2.51 mmol) obtained in step 2 was dissolved in DMF (3.0 mL), and the solution was stirred at room temperature for 6 hours under light shielding after adding N-iodosuccinimide (621 mg, 2.76 mmol). A sodium carbonate aqueous solution was added to the reaction mixture. The precipitated crystals were collected by filteration, and dried under reduced pressure to give 3-iodo-2-isopropyl-6-methylimidazo[1,2-a]pyridine-7-carbonitrile (752 mg, yield 92%).

Workup

  1. customThe precipitated crystals were collected by filteration
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-a775a8d582cd4db590d256a16d860802
Source dataset
uspto-grants-2015_04
Patent number
US09000186B2

Reaction notes

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