Hydrochloric Acid → HCID 68943699, compound

HRID 1468275Notes

Reaction equation

HRID 1468275 reaction equation
[C:1]([C:5]1[N:6]=[C:7]2[CH:12]=[C:11]([C:13]([O:15]CCC)=[O:14])[N:10]=[CH:9][N:8]2[C:19]=1[CH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Li+].Cl>C(O)C>[C:1]([C:5]1[N:6]=[C:7]2[CH:12]=[C:11]([C:13]([OH:15])=[O:14])[N:10]=[CH:9][N:8]2[C:19]=1[CH2:20][CH:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 68941322HCID 68941322, compound

Product 1

HCID 68943699HCID 68943699, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Propyl 2-tert-butyl-3-cyclohexylmethylimidazo[1,2-c]pyrimidine-7-carboxylate (280 mg, 0.783 mmol) obtained in step 1 was dissolved in a 70% ethanol aqueous solution (3.0 mL), and the solution was stirred at room temperature for 1 hour after adding lithium hydroxide.1 hydrate (36.1 mg, 0.862 mmol). Under ice-cooled condition, 3 mol/L hydrochloric acid (0.287 mL) was added to the reaction mixture. The precipitated crystals were collected by filteration, and dried under reduced pressure to give 2-tert-butyl-3-cyclohexylmethylimidazo[1,2-c]pyrimidine-7-carboxylic acid (197 mg, yield 80%).

Workup

  1. additionwas added to the reaction mixture
  2. customThe precipitated crystals were collected by filteration
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-c04eb38ca58b413e9c627398e61975a4
Source dataset
uspto-grants-2015_04
Patent number
US09000186B2

Reaction notes

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