反应详情

To a solution of 7.68 g (30 mmol) of 2,4-difluoro-6-iodophenol (P7), Preparation 7 and 3.03 g (15 mmol) of 1,3-dibromopropane in 125 mL of acetone add 12.42 g (90 mmol) of potassium carbonate. Reflux the resulting reaction mixture for 48 hours. Cool the reaction mixture to room temperature, filter it, and extract the resulting filtrate thoroughly with methylene chloride. Combine methylene chloride extracts and concentrate them by rotary evaporation. Crystallize the resulting solid from hexanes to yield 3.4 g (41.1%) of (P8) as a white solid.

1. temperatureReflux
2. customthe resulting reaction mixture for 48 hours
3. filtrationfilter it
4. extractionextract the resulting filtrate thoroughly with methylene chloride
5. concentrationconcentrate them
6. customby rotary evaporation
7. customCrystallize the resulting solid from hexanes
8. customto yield 3.4 g (41.1%) of (P8) as a white solid