Triethylamine → HCID 565655, compound

HRID 1468584Notes

Reaction equation

HRID 1468584 reaction equation
[CH2:1]([NH2:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH2:9].C(N([CH2:16][CH3:17])CC)C.[O:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[C:23](Cl)=[O:24]>CN(C1C=CN=CC=1)C>[CH2:1]([NH:10][C:23]([C:19]1[O:18][CH:22]=[CH:16][CH:17]=1)=[O:24])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH:9][C:23]([C:19]1[O:18][CH:22]=[CH:21][CH:20]=1)=[O:24]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 242501,8-OctanediamineHCID 682422-Furancarbonyl chloride

Product 1

HCID 565655HCID 565655, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

The general procedure was carried out using 1,8-octanediamine (10.0 g, 69.3 mmol), triethylamine (14.2 g, 141 mmol), DMAP (0.17 g, 1.35 mmol) and furoyl chloride (19.0 g, 146 mmol). The resulting compound was purified by column chromatography (98:2 DCM:EtOAc), and the product obtained as a white solid (21.5 g/92%).

Workup

  1. customThe resulting compound was purified by column chromatography (98:2 DCM:EtOAc)
  2. customthe product obtained as a white solid (21.5 g/92%)

Sources & evidence

ORD record
ord-dfa3fc28e69642749dc63ba83dc3dbae
Source dataset
uspto-grants-2015_04
Patent number
US09005708B2

Reaction notes

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