反应详情

温度

80 °C

A mixture of 2-[5-amino-8-(2-furyl)-1-methyl-2-oxo-[1,2,4]triazolo[5,1-f]purin-3-yl]ethyl 4-methylbenzenesulfonate obtained in step 7 (0.25 g, 0.533 mmol), 1-[4-(2-Methoxy-ethoxy)-phenyl]-piperazine (0.188 g, 0.799 mmol) and DIPEA (0.27 ml, 1.599 mmol) were taken in DMF (5 ml) and stirred at 80° C. for 16 hours. To the reaction mixture water (100 ml) was added and solid obtained was filtered off. The crude product was purified by column chromatography to obtain 5-amino-8-(2-furyl)-3-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one (0.135 g, 47%) as an off white solid

1. customsolid obtained
2. filtrationwas filtered off
3. customThe crude product was purified by column chromatography