反应详情

温度

21 °C

A mixture of 5-amino-8-(2-furyl)-3-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one (0.1 g, 0.18 mmol) obtained in example 1, NaH (0.043 g, 0.18 mmol) and methyl iodode (0.1 ml, 0.18 mmol)in DMF (2 ml) were stirred at 21° C. for 3 hours. To the reaction mixture water (10 ml) was added and solid obtained was filtered. The crude product was purified by column chromatography to obtain 8-(2-furyl)-3-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-1-methyl-5-(methylamino)-[1,2,4]triazolo[5,1-f]purin-2-one. (5 mg, 5%) as an off white solid.

1. customsolid obtained
2. filtrationwas filtered
3. customThe crude product was purified by column chromatography