Imidazole → 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-(1H-imidazol-1-ylmethyl)thiophene-2-carboxamide

HRID 146912Notes

Reaction equation

HRID 146912 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]([NH:8][C:9]([c:10]2[c:11]([NH:17][C:18](=[O:19])[c:20]3[s:21][cH:22][c:23]([CH2:26][Cl:27])[c:24]3[Cl:25])[cH:12][cH:13][c:14]([Cl:16])[cH:15]2)=[O:28])[cH:6][cH:7]1.[Na:34].[O:35]=[CH:36][N:37]([CH3:38])[CH3:39].[nH:29]1[cH:30][n:31][cH:32][cH:33]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([NH:8][C:9]([c:10]2[c:11]([NH:17][C:18](=[O:19])[c:20]3[s:21][cH:22][c:23]([CH2:26][n:29]4[cH:30][n:31][cH:32][cH:33]4)[c:24]3[Cl:25])[cH:12][cH:13][c:14]([Cl:16])[cH:15]2)=[O:28])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 5360545SodiumHCID 18376557N-(4-chlorophenyl)-2-[((4-(chloromethyl)-3-chlorothiophen-2-yl)carbonyl)amino]-5-chlorobenzamide

Product 1

HCID 183766183-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-(1H-imidazol-1-ylmethyl)thiophene-2-carboxamide

Sources & evidence

ORD record
ord-4afb705341b3440db05246c53cd02283
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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