Propargyl alcohol → 3-Hydroxy-1-[4-chloro-2-benzoylphenyl]propyne

HRID 146967Notes

Reaction equation

HRID 146967 reaction equation
[CH2:37]([C:38]#[CH:39])[OH:40].[CH2:44]([NH:45][CH2:46][CH3:47])[CH3:48].[Cl:21][c:22]1[cH:23][cH:24][c:25]([I:36])[c:26]([C:27](=[O:28])[c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[cH:35]1.[I-:20].[Pd:41]([Cl:42])[Cl:43].[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[Cl:21][c:22]1[cH:23][cH:24][c:25]([C:39]#[C:38][CH2:37][OH:40])[c:26]([C:27](=[O:28])[c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[cH:35]1

Participants

7

Reactant 6

HCID 7859Propargyl alcoholHCID 8021DiethylamineHCID 11776TriphenylphosphineHCID 24290Palladium ChlorideHCID 30165Iodide IonHCID 129482625-Chloro-2-iodobenzophenone

Product 1

HCID 128416443-Hydroxy-1-[4-chloro-2-benzoylphenyl]propyne

Sources & evidence

ORD record
ord-da5560f1aa8a4cb08568f6b9a8844f22
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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